论文部分内容阅读
目的观察重组人表皮生长因子(rhEGF)联合重组人碱性成纤维细胞生长因子(rhFGF)对烧伤创面愈合的影响。方法对60例烧伤患者，每例患者选择同一块深度烧伤创面的两部分，分别采用rhEGF法和rhEGF+ rhFGF法换药治疗，评价上述受试创面愈合后的瘢痕指数(SI)及愈合速度。结果 rhEGF+ rhFGF法残余创面愈合时间(12.45±8.42)天,明显少于rhEGF (29.7±10.12)天(t=2.225,P0.05)；愈后2年rhEGF法SI为8.92±1.78，明显低于rhEGF+ rhFGF法6.12±1.54(t=2.116,P<0.05)；所有受试创面均无肿瘤形成、癌变等并发症发生。结论外用重组人表皮生长因子(rhEGF)联合重组人碱性成纤维细胞生长因子(rhFGF)治疗深度烧伤创面,能明显减少后期瘢痕的形成,远期疗效和安全性较好。“,” Objective To observe the effect of recombinant human epidermal growth factor (rhEGF) combined with recombinant human basic fibroblast growth factor (rhFGF) on burn wound healing. Methods 60 cases of burn patients, each patient selection of two parts of the same piece of deep burn wounds, respectively using rhEGF method and rhEGF+ rhFGF method for dressing change, the wound healing and scar index (SI) were evaluated after and. Results The rhEGF+ rhFGF method of residual wound healing time (12.45 ± 8.42) days were less than that of rhEGF (29.7 ± 10.12) days (t=2.225, P0.05); After 2 years index of SI (8.92 ± 1.78) in rhEGF were significantly lower than (6.12 ± 1.54)in rhFGF (t=2.116, P<0.05);; al subjects were no tumor formation, cancer and other complications. Conclusion the recombinant human epidermal growth factor (rhEGF) combined with recombinant human basic fibroblast growth factor (rhFGF) in treating deep burn wound can significantly reduce the scar formation, long-term efficacy and safety.