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在子宫癌的癌变早期,子宫内膜有不同程度的异常增殖和核分裂;在子宫内膜增殖期,内膜细胞的有丝分裂也比较旺盛,此时均有利于染色体标本的制备及核型分析。为此,我们根据青岛医学院妇产科的研究经验,利用门诊病人的子宫内膜直接制备染色体,并在技术及方法学方面进行了探索和研究。经过反复实验,已获得较满意的效果。该方法的建立,不仅对妇女染色体病可迅速诊断,而主要是对子宫内膜癌及癌前病变的早期诊断提供依据,也可以从染色体的早期变异情况进行研究。
In the early stage of carcinogenesis of uterine cancer, the endometrium has abnormal proliferation and mitosis to varying degrees. During the proliferative phase of endometrium, the mitosis of endometrial cells is relatively strong, which is beneficial to the preparation and karyotype analysis of chromosome specimens. Therefore, according to the research experience of obstetrics and gynecology of Qingdao Medical College, we make direct use of the endometrium of outpatients to make chromosomes, and have carried out exploration and research in technology and methodology. After repeated experiments, have been more satisfied with the results. The establishment of this method not only provides a quick diagnosis of chromosomal diseases in women, but also provides a basis for the early diagnosis of endometrial cancer and precancerous lesions, as well as studies on the early variation of chromosomes.