论文部分内容阅读
目的探讨T2DM慢性肾脏疾病(CKD)患者血清胱抑素C(Cys-C)改变及临床意义。方法选取CKD患者83例、T2DM患者98例及健康对照(NC)者100名,比较各组血清Cys-C、β2微球蛋白(β2-MG)、BUN、血清肌酐(Scr)和血清尿酸(SUA)等临床指标。结果 CKD组血清Cys-C水平高于T2DM、NC组,差异有统计学意义(P<0.01),同时测定β2-MG可提高CKD的异常检出率。结论血清Cys-C水平可作为肾小球滤过率(GFR)的判断指标之一,血清Cys-C水平与β2-MG、Scr呈正相关,与CCr呈负相关。
Objective To investigate the changes of serum cystatin C (Cys-C) in patients with T2DM chronic kidney disease (CKD) and its clinical significance. Methods Eighty-three CKD patients, 98 T2DM patients and 100 healthy control subjects were enrolled in this study. Serum levels of Cys-C, β2-microglobulin, BUN, serum creatinine and serum uric acid SUA) and other clinical indicators. Results The level of serum Cys-C in CKD group was significantly higher than that in T2DM and NC groups (P <0.01). The simultaneous detection of β2-MG increased the abnormal detection rate of CKD. Conclusion Serum Cys-C level can be used as a marker of glomerular filtration rate (GFR). Serum Cys-C level is positively correlated with β2-MG, Scr and negatively correlated with CCr.