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目的 探讨血清非对称性二甲基精氨酸（ADMA）水平与冠心病严重程度的相关性。方法 冠脉造影确诊的冠心病患者45例，依据冠心病临床类型分为急性心肌梗死组（n=22例）和心绞痛组（包括稳定型心绞痛和不稳定型心绞痛，n=23）。患者在入院后采集病史，测定心肌酶、三酰甘油（TG）、总胆固醇(TC)、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、高敏C反应蛋白（hs-CRP）和血清ADMA。同时用Syntax积分来评估冠脉狭窄程度，比较组间ADMA水平，分析ADMA水平与TG、TC、LDL-C、HDL-C、hs-CRP以及Syntax积分的相关性。结果 急性心肌梗死组血清ADMA水平(60±24) μg/L显著高于心绞痛组(31±21) μg/L，P<0.05。患者血清ADMA水平与LDL-C、hs-CRP呈正相关。患者血清ADMA水平与冠脉狭窄程度的Syntax积分呈正相关。结论 血清ADMA水平与冠心病严重程度有相关性。
Objective To investigate the relationship between serum asymmetric dimethylarginine (ADMA) levels and the severity of coronary heart disease. Methods Forty-five patients with coronary heart disease diagnosed by coronary angiography were divided into acute myocardial infarction group (n = 22) and angina pectoris group (including stable angina pectoris and unstable angina pectoris, n = 23) according to the clinical type of coronary heart disease. The patients were collected after admission to collect the medical history, and the levels of myocardial enzymes, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) (Hs-CRP) and serum ADMA. The degree of coronary artery stenosis was evaluated by Syntax score. The level of ADMA was compared between groups. The correlation between ADMA level and TG, TC, LDL-C, HDL-C, hs-CRP and Syntax scores was analyzed. Results The level of serum ADMA in acute myocardial infarction group (60 ± 24) μg / L was significantly higher than that in angina group (31 ± 21) μg / L, P <0.05. Serum ADMA levels in patients with LDL-C, hs-CRP was positively correlated. The level of ADMA in patients with coronary artery stenosis was positively correlated with Syntax score. Conclusion The serum level of ADMA is correlated with the severity of coronary heart disease.