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在一项开放研究中,调查了由易感性细菌引起感染的87名患者,用氨噻羧单胺菌素(Aztreon am)治疗的效果。患者均有严重医院内获得性感染,诸如菌血症(11名)、肺炎(8名)囊性纤维化(18名)、腹腔内感染(5名)、伤口感染8名)、骨髓炎、脓毒性关节炎(10名)和泌尿道感染(25名)。按10～140mg/公斤/日量静注或肌注Azt reonam、平均用量为每8～12小时1克或者每8小时2克。需要时另加抗革兰氏阳性菌或厌氧菌的药物,分离出的菌株大多数都对氨基糖甙类、复方增效磺胺噻孢霉素、头孢羟唑、头孢甲氧霉素有抗药
In an open-label study, 87 patients treated with susceptible bacteria were investigated for their efficacy with Aztreonam. Patients had severe nosocomial infections such as bacteremia (11), pneumonia (8) cystic fibrosis (18), intraperitoneal infection (5), wound infection 8), osteomyelitis, Septic arthritis (10) and urinary tract infection (25). At 10 ~ 140mg / kg / day intravenous or intramuscular Azt reonam, the average amount of 1 grams every 8 to 12 hours or 2 grams every 8 hours. If necessary, additional anti-Gram-positive bacteria or anaerobic drugs, isolated strains are mostly on aminoglycosides, compound synergistic sulfasuccinin, cefadroxil, cefmexinomycin resistance medicine