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目的研究绿藻孔石莼Ulva pertusa的化学成分。方法采用硅胶、ODS、Diaion HP-20、Sephadex LH-20等柱色谱和制备HPLC等技术进行分离纯化,根据理化性质和谱学数据鉴定化合物结构。结果从孔石莼乙醇提取物中分离得到18个化合物,分别鉴定为异植物醇(1)、3-吲哚甲酸(2)、1-O-十六碳酰基-3-O-(6′-硫代-α-D-脱氧吡喃葡萄糖基)甘油(3)、(2S)-1-O-十六碳酰基-3-O-[α-D-吡喃半乳糖基-(1→2)-β-D-吡喃半乳糖基]甘油(4)、3-甲基亚砜基丙酸(5)、3-氯丙酸(6)、酪醇(7)、对羟基苯甲酸(8)、对羟基苯乙酸(9)、6-乙烯基己内酯(10)、黑麦草内酯(11)、向日葵香波龙大柱酮D(12)、壬二酸(13)、琥珀酸(14)、8-羟基-(6E)-辛烯酸(15)、3-乙氧基丙酸(16)、正丁基-β-D-吡喃果糖苷(17)、焦谷氨酸正丁酯(18)。结论化合物1~16为首次从孔石莼中分离得到,化合物5、6、10、15和16为首次从天然产物中分离得到,化合物17和18为提取过程中产生的β-D-吡喃果糖苷和焦谷氨酸人工产物。
Aim To study the chemical constituents of Ulva pertusa from the green alga. Methods Silica gel, ODS, Diaion HP-20 and Sephadex LH-20 were separated and purified by column chromatography and preparative HPLC. The structures of the compounds were identified by their physico-chemical properties and spectral data. Results Eighteen compounds were isolated from the ethanol extract of Caragana korshinskii and identified as isophytol (1), 3-indolecarboxylic acid (2), 1-O-hexadecanoyl-3-O- -thio-α-D-glucopyranosylglycerol (3), (2S) -1-O- hexadecanoyl-3-O- [α-D-galactopyranosyl- (1 → 2) -β-D-galactopyranosyl] glycerol (4), 3-methyl sulfoxypropionate (5), 3- chloropropionic acid (6), tyrosol (9), 6-vinylcaprolactone (10), ryegrass lactone (11), sunflower chamberton D (12), azelaic acid (14), 8-hydroxy- (6E) -octenoic acid (15), 3-ethoxypropionic acid (16), n-butyl-β-D-fructopyranoside N-Butyl (18). CONCLUSION Compounds 1 to 16 were isolated from Pseudoterraceae for the first time. Compounds 5, 6, 10, 15 and 16 were isolated from natural products for the first time. Compounds 17 and 18 were isolated from β-D-pyran Fructosyl and pyroglutamate artifacts.