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目的通过建立D-半乳糖致衰老性骨质疏松(SOP)大鼠模型,探讨盐炙杜仲治疗SOP在血生化指标的影响。方法将60只雄性SD大鼠随机分为6组,除了空白对照组外,其他五组均给予腹腔注射D-半乳糖;空白对照组给予腹腔注射同等剂量的生理盐水。8周后造模成功,空白对照组、模型对照组均给予0.5%CMC-Na液灌胃;阳性对照组给予依替膦酸钠灌胃;YL组给予盐炙杜仲低剂量灌胃;YM组给予盐炙杜仲中剂量灌胃;YH组给予盐炙杜仲高剂量灌胃。各组连续给药4周后,采血取材检测血生化指标及BMD测定。结果 YH组血清Ca2+出现了显著的减少,具有统计学意义(P<0.05);YH组血清ALP数值较对照组显著升高,具有统计学意义(P<0.01);高剂量和中剂量杜仲具有显著的升高血清IGF-I的作用(P<0.05和P<0.01)。结论实验证明盐炙杜仲能够降低血钙,提高血清ALP和IGF-I活性,促进钙盐沉积,有利于治疗SOP。
OBJECTIVE: To establish a rat model of senile osteoporosis (SOP) caused by D-galactose and to explore the effect of saltburn decoction on blood biochemical parameters. Methods Sixty male Sprague-Dawley rats were randomly divided into 6 groups. Except for the blank control group, the other five groups were given intraperitoneal injection of D-galactose. The blank control group was given intraperitoneal injection of the same dose of normal saline. After 8 weeks, the models were successfully established. The blank control group and the model control group were given 0.5% CMC-Na solution. The positive control group was given gavage of etidronate. The YL group Given salt Sunburn Eucommia Zhongguanyuwei; YH group given salt Sunburn Eucommia high dose gavage. After four weeks of continuous administration, blood biochemical indexes and BMD were determined. Results Serum Ca2 + was significantly decreased in YH group (P <0.05). The serum ALP level in YH group was significantly higher than that in control group (P <0.01), and the levels of ALP in YH group were significantly lower than those in control group Significantly increased serum IGF-I (P <0.05 and P <0.01). Conclusion Experiments show that salt Sunburn Eucommia can reduce blood calcium, increase serum ALP and IGF-I activity, promote calcium deposition, is conducive to the treatment of SOP.