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目的探讨妊娠期肝内胆汁淤积症(ICP)对母儿的影响。方法将2008年1月～2010年12月本院住院的96例ICP患者(观察组)与同期其他随机抽取的正常孕妇106名产妇(对照组)进行比较。结果 ICP早产儿(25%);胎儿宫内窘迫(31.58%);低体重儿(19.74%);围产儿死亡(3.95%);明显高于对照组(P<0.01)。剖宫产率(87.5%);产后出血(21.88%);明显高于对照组(P<0.01)。结论妊娠期肝内胆汁淤积症对母婴危害极大,应提高认识,加强孕期监护,提高围生儿生存率,降低产科并发症。
Objective To investigate the effect of intrahepatic cholestasis of pregnancy (ICP) on mother and child. Methods Ninety-six ICP patients (observation group) hospitalized in our hospital from January 2008 to December 2010 were compared with 106 pregnant women (control group) of normal pregnant women randomly selected at the same period. Results ICP preterm children (25%), fetal distress (31.58%), low birth weight children (19.74%), perinatal deaths (3.95%) were significantly higher than the control group (P <0.01). Cesarean section rate (87.5%), postpartum hemorrhage (21.88%) was significantly higher than that of the control group (P <0.01). Conclusion Intrahepatic cholestasis of pregnancy is extremely harmful to mothers and infants, so we should raise awareness, strengthen the monitoring of pregnancy, improve the perinatal survival rate and reduce the obstetric complications.