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本实验用透射电镜观察了二例 Creutzfeldt- Jakob病 ( CJD)的尸检及活检脑组织。其中一例为死后 6天尸检脑组织 ,电镜下可见神经元及神经胶质细胞明显变性 ,核染色质块状凝集 ,核碎裂 ,可见细胞碎片。另一例为穿刺活检脑组织 ,因取材过少光镜病理检查只发现脑组织水肿 ,不能明确诊断。电镜观察二例均少见神经元 ,神经胶质细胞多见且变性 ,最突出的表现为脑组织的海绵状界膜空泡变性 ,有髓神经纤维髓鞘解离并有部分溶解 ,轴索溶解消失并呈空泡样变性。本实验表明 :对临床上表现为进行性痴呆 ,脑电图广泛异常的病人的组织活检 ,送检组织过少 ,一般病理检查不能明确诊断时 ,电镜检查具有重要意义 ,即使是死亡 6天后的尸检仍可为 CJD这种疑难和罕见病例的确诊提供有力的证据。
In this experiment, two autopsy and biopsy brain tissues of Creutzfeldt-Jakob disease (CJD) were observed by transmission electron microscopy. One of the cases was autopsy brain tissue 6 days after death. Electron microscope showed obvious degeneration of neurons and glial cells, blockage of nuclear chromatin, nuclear fragmentation and cell debris. Another example is puncture biopsy brain tissue, due to too few light microscopy pathological examination found only brain tissue edema, can not be a clear diagnosis. Electron microscopy were rare in two cases of neurons, glial cells more common and degeneration, the most prominent manifestations of brain tissue of the cavernous membrane degeneration, myelin myelin dissociation and partial dissolution, axonal dissolution Disappeared and vacuolar degeneration. This experiment shows that: the clinical manifestations of progressive dementia, EEG extensive abnormalities in patients with tissue biopsy, submission of tissue too small, the general pathological examination can not be a clear diagnosis, electron microscopy is of great significance, even after 6 days of death Autopsy can provide strong evidence for the diagnosis of difficult and rare cases of CJD.