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目的:观察丙戊酸钠对妊娠小鼠的不良反应,探讨叶酸对其不良效应的干预效果。方法:将60只雌性和30只雄性小鼠随机分为3组(每组30只,雌雄比例2∶1),分别为:①对照组为灌胃蒸馏水10 ml/kg;②实验组为灌胃丙戊酸钠200 mg/kg;③干预组为灌胃丙戊酸钠200 mg/kg+叶酸0.07 mg/kg。观察小鼠的受孕率,妊娠小鼠的流产率、畸形率、死胎率,每窝仔鼠的数目及孕期增重情况等指标。结果:实验组小鼠的受孕率最低,对照组次之,干预组最高(P<0.05)。实验组妊娠小鼠的流产率、畸胎率和死胎率最高,对照组次之,干预组最低;而每窝正常仔鼠数目和孕期增重最少,对照组次之,干预组最多(P<0.05)。结论:丙戊酸钠可导致孕鼠的妊娠意外增多,补充叶酸可降低不良反应的风险。
Objective: To observe the adverse reactions of sodium valproate in pregnant mice and to explore the intervention effect of folic acid on its adverse effects. Methods: 60 female and 30 male mice were randomly divided into 3 groups (30 in each group, the ratio of male and female was 2: 1), respectively: ① the control group was fed with distilled water 10 ml / kg; ② the experimental group was irrigation Sodium valproate 200 mg / kg; ③ intervention group was intragastric sodium valproate 200 mg / kg + folic acid 0.07 mg / kg. Observe the pregnancy rate of mice, pregnancy abortion rate, deformity rate, stillbirth rate, the number of litters per litter and pregnancy weight gain and other indicators. Results: The mice in experimental group had the lowest conception rate, followed by the control group and the highest in intervention group (P <0.05). In the experimental group, the abortion rate, the rate of teratogenicity and the stillbirth rate of the pregnant mice were the highest, followed by the control group and the lowest in the intervention group. The number of normal pups and the least weight gain during pregnancy were the lowest in the control group and the most in the intervention group (P < 0.05). CONCLUSIONS: Sodium valproate can cause an unexpected increase in pregnancies during pregnancy, and folic acid supplementation reduces the risk of adverse events.