在压制药片中的润滑问题,已有很多理论文章发表,但 在实际工作中仍然会遇到问题,从而产生粘冲、裂片、压片 中物料和机器磨耗等,磨耗包括颗粒之间的磨耗和物料在 上下冲与冲模之间的磨耗。这类摩擦会导致径向和轴向的 力转递减弱,从而使片子中的孔隙和密度分布不均。这会造 成片重差异、裂片和分层。在片子压出时,摩擦力有可能损 坏机器和片子。在压片过程中产生的高温也会影响片剂的 稳定性。在片剂处方中加入润滑剂的目的就是减少摩擦力, 同时,可保证压片过程的规律性,使设备及其部件不至于损坏。常用的润滑剂有脂肪酸、脂肪酸盐、脂肪酸酯、水溶性润 滑剂等。 由于大部分润滑剂是疏水性的,有时可能与片剂的组 份相互作用,所以会造成片剂崩解时限延长,影响溶出速 率、张力强度、脆碎性。分散片和泡腾片需要水溶性的润滑 Lubrication in compressed tablets has been published in many theoretical articles, but problems still remain in practical work, resulting in sticky punches, slivers, materials in the tablet and machine wear, etc. The wear includes the wear between the particles and Materials in the upper and lower punch and die wear. This type of friction results in weakened radial and axial force transfer, which results in uneven distribution of porosity and density in the sheet. This can cause weight differences, splits and delamination. Friction may damage the machine and the film as the film is pushed out. The high temperatures that occur during tabletting can also affect the stability of the tablet. The purpose of adding lubricant in the tablet prescription is to reduce friction, at the same time, to ensure the regularity of the tabletting process, so that the device and its components will not be damaged. Commonly used lubricants are fatty acids, fatty acid salts, fatty acid esters, water-soluble lubricants. Because most lubricants are hydrophobic and can sometimes interact with the components of the tablet, they can result in prolonged disintegration of the tablet, affecting dissolution rate, tensile strength, and friability. Dispersing tablets and effervescent tablets require water-soluble lubrication