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长期以来一直认为 Epstein-Barr 病毒(EBv)主要是一种嗜 B 淋巴细胞病毒。这种趋向性表现为 EBV 与各种 B 淋巴细胞增生性疾病、B 细胞肿瘤相关。然而,现在有重要证据提示,容许 EBV 在其中复制的细胞是上皮细胞,而 B 细胞感染可能只是继发的。重新评价上皮在 EBV 持久感染中所起的作用,以及免疫应答在持久性 EBV 感染中的重要性表明,T细胞介导的、针对上皮 EBV 感染的细胞免疫,对维持 EBV 与宿主之间正常的微妙平衡,具有重要意义;EBV 在咽部上皮内无限制地复制,对某些(甚至所有)EBV 相关淋巴瘤的演变形成,可能具有关键性的意义。
It has long been believed that the Epstein-Barr virus (EBv) is mainly a B lymphotropic virus. This tropism is manifested as EBV associated with various B lymphoproliferative diseases and B cell tumors. However, there is now important evidence that the cells that allow EBV to replicate are epithelial cells, whereas B cell infection may be secondary. Reassessing the role of epithelium in persistent infection with EBV and the importance of immune responses in persistent EBV infection suggest that T cell-mediated cellular immunity against epithelial EBV infection maintains normality between EBV and host The delicate balance is important; EBV replicates without restriction within the pharyngeal epithelium and may be critical for the evolution of certain (even all) EBV-associated lymphomas.