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目的探讨不同糖代谢人群胰岛素抵抗和胰岛β功能。方法 1109例行OGTT及胰岛素释放试验,按照血糖结果分为正常糖耐量(NGR)组161例,糖调节异常(IGR)组276例,糖尿病(DM)组672例,均按稳态模型计算胰岛素抵抗指数(HOMA-IR)。结果 NGR与IGR组、DM组相比HOMA-IR有显著差异性(P=0.032,P<0.01);HOMA-β有显著差异性(P<0.01,P<0.01);IGR组与DM组相比HOMA-IR有显著差异性(P<0.01);HOMA-β有显著差异性(P<0.01)。结论 HOMA-IR、HOMA-β在不同糖代谢结果不同,具有统计学意义,是评估糖代谢人群胰岛功能的良好指标。
Objective To investigate the insulin resistance and pancreatic β function in different glycometabolism population. Methods 1109 routine OGTT and insulin release test were divided into normal glucose tolerance (NGR) group, 161 cases, 276 cases of abnormal glucose regulation group (IGR) and 672 cases of diabetic group (DM) Resistance index (HOMA-IR). Results HOMA-IR was significantly different between NGR group and DM group (P = 0.032, P <0.01), HOMA-β was significantly different (P <0.01, P <0.01) HOMA-IR was significantly different (P <0.01); HOMA-β was significantly different (P <0.01). Conclusions HOMA-IR and HOMA-β have different statistical significance in different glucose metabolism, which is a good indicator to evaluate the islet function of glucose-metabolized population.