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白血病是一种克隆性恶性疾病.白血病细胞不能继续分化成熟,停滞在某一阶段并呈恶性增殖.但也有正常髓系造血细胞相应分化阶段的表型.许多研究表明,体内有一白血病祖细胞亚群,维持着白血病细胞的大量增殖,在半固体培养时能形成集落单位,称为白血病克隆形成细胞(L-CFC).L-CFC的DNA合成活跃,具有自身复制和形成二级克隆的能力,核型分析进一步证实了它们的白血病本质.充分认识正常髓系造血细胞各阶段和L-CFC的表型特征,对于进一步阐明髓系造血细胞分化成然和L-CFC发生的生物学性质具有十分重要的意义.
Leukemia is a clonal malignant disease. Leukemia cells can not continue to differentiate and mature, stagnant at a certain stage and showed malignant proliferation. But there are also phenotypes of normal differentiation phase of myeloid hematopoietic cells. Many studies have shown that there is a leukemic progenitor cell in vivo. The population maintains a large proliferation of leukemic cells and can form colony units in semi-solid cultures, called leukemia clone-forming cells (L-CFC). The DNA synthesis of L-CFC is active, with its ability to replicate itself and form secondary clones. The karyotype analysis further confirms the nature of their leukemias. Fully understand the phenotypes of L-CFCs at various stages of normal myeloid hematopoietic cells and provide a further understanding of the biological properties of myeloid hematopoietic differentiation and L-CFC production. Very important significance.