论文部分内容阅读
本文作者详细地叙述了维生素D的代谢及其调节,特别指出了代谢过程中,维生素D和它的前质D_3,以及代谢过程中产生的1,25二羟维生素D[1,25(OH)_2D]对细胞生长和分化的调节作用。文章指出,1,25(OH)_2D在许多细胞和组织中,均有受体,还具有激素的生物学作用,可影响矿物质的代谢。据报道,缺乏维生素D的佝偻病儿童的贫血和骨髓纤维化,使用维生素D后,有明显好转。这些病者的白细胞缺乏随意运动的能力,吞噬细菌的能力也有缺陷,因而常有感染。维生素D缺乏的老鼠,炎症反应受到抑制,巨噬细胞的吞噬作用有缺陷,巨噬细胞和自细胞缺乏自发的游走能力。而这些缺陷,经使用,1,25二羟维生素D_3[1,25(OH)_2D_3]后,可得到纠正。
The author of this article described in detail the metabolism of vitamin D and its regulation, pointing out in particular the metabolic process, vitamin D and its precursor D_3, and 1,25 dihydroxyvitamin D [1,25(OH) produced during metabolic processes. _2D] Regulation of cell growth and differentiation. The article points out that 1,25(OH)2D has receptors in many cells and tissues and also has the biological effects of hormones, which can affect the metabolism of minerals. It has been reported that anemia and bone marrow fibrosis in children with rickets that lack vitamin D significantly improved after using vitamin D. The white blood cells of these patients lack the ability to exercise freely, and their ability to engulf bacteria is also flawed, and infections often occur. In mice lacking vitamin D, the inflammatory response was inhibited, macrophage phagocytosis was defective, and macrophages and autologous cells lacked spontaneous migration ability. These defects can be corrected by using 1,25-dihydroxyvitamin D 3 [1,25(OH)_2D_3].