论文部分内容阅读
部分129/J近交系小鼠抗日本血吸虫和曼氏血吸虫感染的特性引起了免疫寄生虫学家的关注。129/J小鼠的抗感染表现为在血吸虫感染后3～4周,其肠系膜静脉无童虫或也无成虫。同一组129/J小鼠,抗血吸虫感染率可有50～100％的变化。近年来Elsaghier等研究表明,129/J小鼠感染血吸虫数周和数月后,在其肺部发现有发育良好的成虫,多数虫体皮层受损并逐渐开始脱落。129/J与对血吸虫易感的BALB/c小鼠和(BALB/c×129/J)F_1杂交小鼠的抗体反应比较分析表明,129/J小鼠对26kD(Sj26)日本血吸虫谷胱甘肽S-转移酶同工酶(GST)有较强的反应。在感染曼氏血吸虫期间,对同源
Some 129 / J inbred mouse anti-Schistosoma japonicum and Schistosoma mansoni infection caused the characteristics of immune parasites scientists attention. The anti-infective performance of 129 / J mice was shown to be free from or without adult worms in the mesenteric vein 3-4 weeks after schistosome infection. The same group of 129 / J mice, the infection rate of schistosomiasis can have 50 to 100% change. In recent years, Elsaghier and other studies have shown that 129 / J mice infected with Schistosoma several weeks and months later, in their lungs found well-developed adult, most of the worms cortex damage and gradually began to fall off. The comparative analysis of the antibody responses between 129 / J and BALB / c mice and (BALB / c × 129 / J) F_1 hybrid mice susceptible to Schistosoma japonicum showed that 129 / J mice showed no significant effect on 26kD (Sj26) Schistosoma japonicum glutathione Peptide S-transferase isoenzyme (GST) have a stronger response. During the infection of Schistosoma mansoni, homologous