一般认为先天性无胸腺裸鼠是检查人类及非人类细胞株致肿瘤性的最敏感动物之一。通常采用皮下接种进行检查。最近有人将一些类淋巴母细胞株接种到成年裸鼠脑内,发现脑部非常有利于肿瘤生长。作者采用人结肠腺癌细胞株接种到成年裸鼠脑内,皮下和肌内,以比较不同途径对肿瘤形成的影响。 Congenital athymic nude mice are generally considered to be one of the most sensitive animals for examining tumorigenicity in human and non-human cell lines. Subcutaneous inoculation is usually used for examination. Recently, some lymphoblastoid strains have been inoculated into the brain of adult nude mice, and it has been found that the brain is very conducive to tumor growth. The authors inoculated human colon adenocarcinoma cell lines into the brain of adult nude mice, subcutaneously and intramuscularly to compare the effect of different pathways on tumor formation.