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建立大鼠肾母细胞瘤模型。方法用１，２－二甲基肼（１，２－ｄｉｍｅｔｈｙｌｈｙｄｒａｇｉｎｅ，ＤＭＨ）按２００ｍｇ／ｋｇ一次性皮下注射于Ｗｉｓｔａｒ幼鼠，１年内观察肿瘤生长情况。结果３６只经ＤＭＨ处理过的Ｗｉｓｔａｒ鼠，２２只（６１．１％）出现肾脏肿瘤。其中单侧肾肿瘤１７只，双侧肾肿瘤５只（２２．７％）。在所发生的２７个肿瘤肿块中，２１个（７７．８％）肿块经病理证实为肾母细胞瘤。结论肿瘤的表型和超微结构特点与人肾母细胞瘤相似。该模型可作为临床治疗的动物模型，并可用于研究该肿瘤的发病机制。
Establishment of rat nephroblastoma model. Methods Wistar rats were injected subcutaneously with 1,2-dimethylhydragine (DMH) at 200mg / kg for 1 year to observe the growth of tumor. Results Twenty-four DMH-treated Wistar rats developed renal tumors in 22 (61.1%). There were 17 unilateral renal tumors and 5 bilateral renal tumors (22.7%). Of the 27 tumor mass lesions that occurred, 21 (77.8%) masses were pathologically confirmed as nephroblastoma. Conclusion The phenotype and ultrastructure of tumors are similar to human nephroblastoma. The model can be used as an animal model of clinical treatment and can be used to study the pathogenesis of the tumor.