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为进一步观察比较抗生素８９－０７与庆大霉素（ＧＭ）、阿米卡星（ＡＭＫ）对耳蜗形态的影响，本试验用１２３只豚鼠，以等效剂量给药２８ｄ，停药１ｄ后处死，取颞骨观察耳蜗铺片及火棉胶连续切片，并用扫描电镜进行形态学观察，根据毛细胞坏死数与形态观察，阴性对照生理盐水与抗生素８９－０７无显著差异，而盐水与ＧＭ和ＡＭＫ有非常显著的差异。抗生素８９－０７本身与ＧＭ、ＡＭＫ也有极其显著的差异，ＧＭ、ＡＭＫ的量效关系显著，而抗生素８９－０７不存在明显的量效关系。可见抗生素８９－０７对耳蜗形态学无明显影响。而ＧＭ、ＡＭＫ对耳蜗的损伤明显
To further observe and compare the effect of antibiotic 89-07 and gentamycin (GM) and amikacin (AMK) on cochlear morphological changes, 123 guinea pigs were administered at the equivalent dose for 28 days. , And the temporal cortex was used to observe the cochlear implants and the collomant continuous sections. Morphology was observed by scanning electron microscopy. According to the number of hair cells necrosis and morphological observation, there was no significant difference between the negative control saline and the antibiotic 89-07, There are very significant differences. There was also a significant difference between antibiotic 89-07 and GM and AMK. The dose-response relationship between GM and AMK was significant, but the antibiotic 89-07 did not show a significant dose-response relationship. Shows antibiotic 89-07 no significant effect on cochlear morphology. The GM, AMK damage to the cochlear obvious