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对我院儿科诊治的241例临床病例进行分析,作纤维胃镜检查220例(占本组病例的91.2%),其中157例为慢性浅表性胃炎(CSG);十二指肠溃疡61例,53例合并CSG;胃粘膜正常2例。213例作了HP胃粘膜快速脲素酶检测(HPUT),阳性83例,占受检病例的38.9%。107例作了组织学检查,全部病例未见胃粘膜肠化生或十二指肠胃型上皮化生。164例作了血清GAP-IgG检测,阳性117例(占71.3%),抗体滴度越高,粘膜损伤的程度越重;作血清GAP-IgM检测86例,阳性66例(占76.7%),均有明显的临床症状,粘膜HPUT阳性。故GAP-IgG可作为临床判断其病情程度的指标之一。GAP-IgM可作为检测现症病人的一个指标。小儿胃炎及消化性溃疡的组织学改变以胃粘膜炎症反应为主,未见胃粘膜肠化生或十二指肠胃型上皮化生发生,肠化生是发生胃癌的危险因素之一,这可能是小儿较少发生胃癌的原因之一。
241 cases of pediatric diagnosis and treatment in our hospital were analyzed for fiber gastroscopy 220 cases (91.2% of the patients in this group), of which 157 cases of chronic superficial gastritis (CSG); duodenal ulcer in 61 cases, 53 cases with CSG; normal gastric mucosa in 2 cases. 213 cases of HP gastric mucosal rapid urease test (HPUT), 83 were positive, accounting for 38.9% of the cases examined. 107 cases were histologically examined, all cases did not see gastric mucosal intestinal metaplasia or duodenal gastric metaplasia. Serum GAP-IgG was detected in 164 cases (117 positive cases, 71.3%). The higher the antibody titer was, the more severe mucosal damage was. Serum GAP-IgM was detected in 86 cases (66.7%), Have obvious clinical symptoms, mucosal HPUT positive. Therefore, GAP-IgG can be used as one of the indicators of clinical severity of the disease. GAP-IgM can be used as an indicator of detection of patients with disease. Histological changes of gastritis and peptic ulcer in children with gastric mucosal inflammatory response, no gastrointestinal metaplasia or duodenal gastric epithelial metaplasia occurs, intestinal metaplasia is one of the risk factors for gastric cancer, which may be One of the causes of gastric cancer in children less incidence.