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目的探讨双水平气道正压通气(BIPAP)呼吸机无创通气治疗慢性阻塞性肺疾病(COPD)并Ⅱ型呼吸衰竭的疗效。方法 68例(COPD)患者随机分为观察组和对照组各34例,观察组在常规治疗基础上,采用BiPAP呼吸机通气治疗;对照组予呼吸兴奋剂治疗。对两组患者呼吸、心率、血氧饱和度及血气变化进行比较。结果两组动脉二氧化碳分压(PaCO2)、动脉氧分压(PaO2)、呼吸频率(RR)、治疗前后心率(HR)及pH值相比经统计学处理差异显著(P<0.05),且RR和PaCO2治疗后72h治疗组改善程度更优于对照组,差异具有显著性(P<0.05);PaO2、HR和pH改善程度也优于对照组,但差异无显著性(P>0.05)。结论 BiPAP呼吸机治疗COPD合并Ⅱ型呼吸衰竭的效果显著。选择合适的通气模式和参数,是治疗成功的关键。
Objective To investigate the efficacy of noninvasive ventilation with bipolar positive airway pressure (BIPAP) ventilator in treating chronic obstructive pulmonary disease (COPD) and type Ⅱ respiratory failure. Methods Sixty-eight patients (COPD) were randomly divided into observation group (34 cases) and control group (34 cases). The observation group was treated with BiPAP ventilator ventilation on the basis of routine treatment, while the control group was treated with respiratory stimulant. The two groups of patients breathing, heart rate, oxygen saturation and blood gas changes were compared. Results The PaCO2, PaO2, RR, HR and pH of the two groups were significantly different (P <0.05) compared with those of the control group (P <0.05). The improvement of PaO2, HR and pH was also better than that of the control group, but the difference was not significant (P> 0.05). Conclusion BiPAP ventilator is effective in treating COPD with type Ⅱ respiratory failure. Choosing the right ventilation pattern and parameters is the key to successful treatment.