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慢性肾功能衰竭(CRF)是各种慢性肾脏疾患肾功能恶化的结果,引起肾脏排泄、分泌及调节功能的减退,水与电解质紊乱及氮质血症。透析与肾移植虽然使不少CRF患者延长了生命,但国外报道,慢性血透患者的病死率每年为10％,其中50～60％死于心血管并发症,25～30％为急性心肌梗塞(AMI)所致。CRF心衰为一种难治性心力衰竭,与AMI同时或先后存在,更增加了治疗上的困难。 CRF对心血管系统的影响 高血压与动脉粥样硬化是不少CRF患者心血管系统的主要病变,高血压性肾血管病变是CRF的一种原因。CRF时,蛋白质、糖及脂肪的代谢以及肾脏内分泌系统(肾素-血管紧张素-醛固酮及前列腺素等系统)的功能发生了紊乱,使血管舒缩功能及水盐代谢的调节发生障碍,促进了高血
Chronic renal failure (CRF) is a result of worsening renal function in various chronic kidney disorders, causing renal excretion, diminished secretion and regulation, water and electrolyte disturbances, and azotemia. Dialysis and kidney transplantation, although many patients with CRF prolong life, but the foreign reports, the mortality of patients with chronic hemodialysis every year 10%, of which 50 to 60% died of cardiovascular complications, 25 to 30% of acute myocardial infarction (AMI) due. CRF Heart failure is a refractory heart failure, with or without AMI, which adds to the therapeutic difficulties. The impact of CRF on the cardiovascular system Hypertension and atherosclerosis are the major cardiovascular diseases in many patients with CRF. Hypertensive renal disease is a cause of CRF. CRF, protein, sugar and fat metabolism and renal endocrine system (renin - angiotensin - aldosterone and prostaglandin system) function disorder, the regulation of vasomotor function and water and salt disorders, promote High blood