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目的评价百草枯的急性毒性特点,为中毒治疗提供参考依据。方法按国家标准《农药登记毒理学试验方法》(GB15670-1995)进行了小鼠急性经口毒性、豚鼠急性经皮毒性、家兔急性眼刺激性和家兔急性皮肤刺激性毒性试验研究。结果百草枯对雌、雄性小鼠急性经口LD50值分别为108.0 mg/kg.BW和126.0 mg/kg.BW,属中毒性。对雌、雄性豚鼠急性经皮LD50值分别为233.0 mg/kg.BW和200.0 mg/kg.BW,属中毒性。对家兔急性眼刺激性试验结果为轻度至中度刺激性,对家兔急性皮肤刺激性试验结果为中度刺激性。毒性特点为百草枯急性中毒可造成全身各器官组织的损伤,持续时间较长,恢复缓慢。结论百草枯毒性较大,可迅速吸收而造成多器官组织严重损害,中毒治疗应尽早采取有效的方法,全面保护和减轻中毒器官组织的损伤。
Objective To evaluate the acute toxicity of paraquat and provide a reference for the treatment of poisoning. Methods Acute oral toxicity, acute dermal toxicity in guinea pigs, acute ocular irritation in rabbits and acute skin irritation in rabbits were studied in accordance with the national standard “Pesticide Registration Toxicology Test Method” (GB15670-1995). Results The acute oral LD50 values of paraquat in female and male mice were 108.0 mg / kg.BW and 126.0 mg / kg.BW, respectively. Acute dermal LD50 values of 233.0 mg / kg.BW and 200.0 mg / kg.BW for both female and male guinea pigs were toxic. Acute eye irritation test results for rabbits mild to moderate irritation, rabbit acute skin irritation test results were moderate irritation. Toxicity characterized by acute paraquat poisoning can cause systemic organ damage, longer duration, slow recovery. Conclusion Paraquat is more toxic and can be quickly absorbed and causes serious damage to multiple organs and tissues. As soon as possible, effective treatment should be taken to prevent and treat poisonous organ tissues.