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目的探讨各种不同乙型肝炎病毒感染模式与血清HBV Pre-S1抗原(Pre-S1)及HBV DNA载量之间的相互关系,为临床乙型肝炎的诊断和治疗提供参考依据。方法对1037例临床血清标本同时检测乙肝标志物、Pre-S1及HBVDNA载量。结果 HBsAg、HBeAg、HBcAb阳性模式组(“大三阳”)的Pre-S1阳性率显著高于其余各血清模式组(P<0.05);“大三阳”模式组的HBVDNA阳性率高于其余各血清模式组(P<0.05)。“大三阳”组的HBVDNA载量显著高于“小三阳”组(P<0.05);“小三阳”模式组与HBsAg、HBcAb阳性模式组相比,HBV DNA水平无显著性差异(P>0.05)。结论 HBV DNA定量检测在预防HBV的感染方面具有重要意义;HBV血清标志物、Pre-S1和HBV DNA载量三者联合检测有利于全面监测乙肝病情和提高乙肝疗效。
Objective To investigate the relationship between different HBV infection patterns and the serum Pre-S1 antigen (HBV) and HBV DNA load, and to provide a reference for the diagnosis and treatment of hepatitis B. Methods Serum samples of 1037 cases were tested simultaneously for HBV markers, Pre-S1 and HBVDNA load. Results The positive rate of Pre-S1 in HBsAg, HBeAg and HBcAb positive groups (“Dasanyang”) was significantly higher than that in other serum groups (P <0.05) Rate was higher than the rest of the serum model group (P <0.05). Compared with HBsAg and HBcAb positive model group, the HBV DNA level in “Sansanyang” group was significantly higher than that in “Sanyangyang” group (P <0.05) Significant difference (P> 0.05). Conclusion The quantitative detection of HBV DNA is of great significance in preventing HBV infection. The combined detection of HBV serum markers, Pre-S1 and HBV DNA load is helpful to comprehensively monitor the condition of hepatitis B and improve the efficacy of hepatitis B treatment.