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目的丙型肝炎病毒抗体(HCV-Ab)阳性样本同时检测丙型肝炎病毒RNA(HCV-RNA)及丙肝核心抗原(HCV-cAg),探讨丙肝核心抗原检测对于慢性丙型肝炎病毒感染的意义。方法筛选出丙型肝炎病毒感染(HCVAb阳性)患者260例,同时检测HCV-RNA和HCV-cAg,分析HCV-cAg在HCV-Ab阳性患者中的阳性率及HCVcAg与HCV-RNA的相关性。结果 260例HCV-Ab阳性患者,其中140例HCV-Ab及HCV-RNA均阳性,另120例HCV-Ab阳性,HCV-RNA阴性;HCV-cAg总阳性数104例,阳性率为40.0%;140例HCV-Ab及RNA双阳性患者,HCV-cAg阳性数101例,阳性率为72.1%,RNA浓度越高与HCV-cAg的相关性越好。结论丙型核心抗原与丙肝RNA相关性较强,丙型核心抗原检测能够有效反映HCV病毒复制状况,操作简便,费用低廉,在临床上具有很好的推广前景。
Objective To detect HCV-RNA and hepatitis C core antigen (HCV-cAg) simultaneously in hepatitis C virus (HCV) -b positive samples to explore the significance of detection of hepatitis C core antigen in chronic hepatitis C virus infection. Methods A total of 260 patients with HCV infection (HCVAb positive) were screened out for detection of HCV-RNA and HCV-cAg at the same time. The positive rate of HCV-cAg in HCV-Ab positive patients and the correlation between HCVcAg and HCV-RNA were analyzed. Results Among 260 HCV-Ab positive patients, 140 were positive for HCV-Ab and HCV-RNA, and the other 120 were HCV-Ab positive and HCV-RNA negative. The total positive count of HCV-cAg was 104, with a positive rate of 40.0% In 140 cases of HCV-Ab and RNA double positive, the positive rate of HCV-cAg was 101.1%, the positive rate was 72.1%. The higher the RNA concentration, the better the correlation with HCV-cAg. Conclusion The C core antigen is highly correlated with HCV RNA, and the detection of C core antigen can effectively reflect the replication status of HCV virus. It is easy to operate and has low cost and has a good promotion prospect in clinic.