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通过在ＤＣＣ（二环已基碳酰二亚胺）存在下用４β－氨基－４－去氧－４′－去甲表鬼臼毒与卤代苯甲酸缩合，合成了１２个新的４β－卤代芳香酰胺基－４－去氧－４′－去甲表鬼臼毒衍生物（２～１３）．测定了这些化合物对ＫＢ，ＨＣＴ－８，Ａ－２７８０和ＨｅＬａ－６０细胞的杀伤效应（体外细胞试验）．结果显示，这些化合物中大多数比目前临床使用的抗癌药物依托泊甙，即ＶＰ－１６在ＨＣＴ－８，Ａ－２７８０和ＨｅＬａ－６０细胞的杀伤中有较强的效果．对这些化合物进行了大鼠肝微粒体脂质过氧化试验．结果显示这些化合物具有明显的抗脂质过氧化能力．用ＱＳＡＲ（定量的结构－活性相关关系）方法分析了该类化合物的结构和对ＫＢ，ＨＣＴ－８和ＨｅＬａ－６０细胞抑制作用间的相互关系
By condensing 4β-amino-4-deoxy-4’-norvulopodin with halobenzoic acid in the presence of DCC (dicyclohexylcarbodiimide), 12 new 4β- Haloaromatic amide-4-deoxy-4’-norvulopodophyllotoxin derivatives (2-13). The killing effect of these compounds on KB, HCT-8, A-2780 and HeLa-60 cells was determined (in vitro cell assay). The results show that the majority of these compounds have a stronger effect than the current clinical use of the anticancer drug etoposide, VP-16 in the killing of HCT-8, A-2780 and HeLa-60 cells. The rat liver microsomal lipid peroxidation test was performed on these compounds. The results show that these compounds have significant anti-lipid peroxidation ability. The QSAR (quantitative structure-activity relationship) method was used to analyze the relationship between the structure of these compounds and the inhibitory effect on KB, HCT-8 and HeLa-60 cells