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目的探讨性激素结合球蛋白(SHBG)在妊娠期糖尿病(GDM)监测中的价值。方法选取2015-01-12在我院做常规产前检测的孕妇400例,在孕24~28周时进行口服葡萄糖耐量试验(OGTT),同时测定SHBG。根据OGTT结果将孕妇分为妊娠期糖尿病组、糖耐量异常组和糖耐量正常组。比较3组OGTT结果和SHBG水平,评估SHBG在妊娠期糖尿病监测中的价值。结果单因素方差分析结果表明,3组空腹血糖,餐后1、2h及SHBG平均水平都存在明显差异。GDM组空腹血糖,餐后1、2h血糖水平均高于其他2组,SHBG水平低于其他2组,差异有统计学差异,P<0.05。结论 SHBG水平的检测对GDM筛查有重要意义,同时还可通过SHBG水平降低程度判定GDM的发生发展及严重程度,为GDM患者进行科学的干预治疗提供依据。
Objective To investigate the value of sex hormone binding globulin (SHBG) in the monitoring of gestational diabetes mellitus (GDM). METHODS: Four hundred pregnant women with routine prenatal tests in our hospital from January 2015 to January 2015 were enrolled in this study. Oral glucose tolerance test (OGTT) and SHBG were performed at 24 to 28 weeks gestation. According to OGTT results, pregnant women were divided into gestational diabetes mellitus group, impaired glucose tolerance group and normal glucose tolerance group. The OGTT results and SHBG levels were compared between the three groups to evaluate the value of SHBG in the monitoring of gestational diabetes mellitus. Results One-way analysis of variance showed that there were significant differences in fasting blood glucose, postprandial 1,2 h and mean SHBG levels among the three groups. The level of fasting blood glucose in GDM group was higher than that in the other two groups at 1h and 2h after meal, and the level of SHBG was lower than the other two groups (P <0.05). Conclusion The detection of SHBG level is of great significance for the screening of GDM. At the same time, the development and severity of GDM can be judged by the degree of SHBG reduction, which provides a basis for scientific intervention in GDM patients.