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从1918年酒石酸锑钾用于临床治疗血吸虫病以来,在长达半个世纪的时间里,药物化学、药理学、生物化学和临床学工作者,进行了很多的工作,希望能找到一个可以取代锑剂的非锑化合物。迄今为止,筛选的化合物虽估计多达25万个,也发现一些对实验动物防治有效的药物,但能实际应用于临床治疗的,只有很少几种,且仍有不少缺点,说明寻找防治血吸虫病新药的工作还相当艰巨。一、非锑类药物的研究近年来,根据药物的不同作用,把防治血吸虫病的药物分为三种类型(1)预防药物。这类药物是用以防止血吸虫尾蚴进入宿主体内或杀死宿主体内的童虫;(2)抑制排卵药。此类药物不需对虫体产生不可逆的变化,但可抑制雌虫排卵,从而保护施主机体不受虫卵的损害,并防止病原扩散,在流行病学上起到一定的控制作用;(3)治疗药物。是指杀死成虫的一
For more than half a century, pharmaceutical chemists, pharmacologists, biochemists and clinical scientists have done a great deal of work since 1918 when antimony potassium tartrate was used in the clinical treatment of schistosomiasis, hoping to find an alternative Antimony agent non-antimony compounds. So far, although the screening of compounds estimated as many as 250,000, but also found that some of the experimental animals effective anti-control drugs, but can be actually applied to clinical treatment, there are only a few, and there are still many shortcomings, indicating that the search for control The new drug for schistosomiasis is still a daunting task. First, non-antimony drugs in recent years, according to the different effects of drugs, the prevention and treatment of schistosomiasis drugs are divided into three types (1) preventive drugs. Such drugs are used to prevent Schistosoma japonicum cercariae into the host or kill the host of the schistosomiasis; (2) to suppress ovulation drugs. Such drugs do not have irreversible changes in parasites, but can inhibit female ovulation, thereby protecting the host organism from egg damage and prevent the spread of pathogens, play a certain epidemiological control role; (3) )medicine. One that kills adults