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FEZ1基因定位于染色体8p22,其编码相对分子质量为67×103的亮氨酸拉链蛋白,具有生长调节作用。FEZ1基因对人类许多恶性肿瘤的发生发展起着非常重要的作用,包括前列腺癌、胃癌、头颈癌、膀胱癌、肝细胞癌、胆管癌,以及血液系统恶性疾病。该基因在这些恶性肿瘤中存在缺失或下调,但产生的具体原因尚不明确。FEZ1基因的功能除了能抑制肿瘤细胞的生长、调节细胞有丝分裂外,近年来的研究表明,其还能与驱动蛋白及微管蛋白相互作用,参与调节神经的生长,并与精神分裂症的发生相关,故FEZ1基因可能为一种细胞生长调控基因。
The FEZ1 gene is located on chromosome 8p22, which encodes a leucine zipper protein with a relative molecular mass of 67 × 103, which has a growth regulatory effect. The FEZ1 gene plays a very important role in the development and progression of many human malignancies including prostate cancer, stomach cancer, head and neck cancer, bladder cancer, hepatocellular carcinoma, cholangiocarcinoma, and hematological malignancies. The gene exists in these malignant tumors deletion or down, but the specific reasons for the production is not yet clear. In addition to inhibiting the growth of tumor cells and regulating cell mitosis, the function of FEZ1 gene in recent years has shown that it can interact with kinesin and tubulin to regulate the growth of the nerve and is associated with the occurrence of schizophrenia , So FEZ1 gene may be a cell growth regulatory genes.