糖尿病性外周神经病变是糖尿病常见慢性并发症之一,临床经典药物治疗有三环类抗抑郁药、麻醉药、非甾体类抗炎药和营养神经药物四类,但疗效不佳。本文综述临床非经典药物治疗该病,供临床医师参考。1　抗栓酶类[1、2]本类常用药物为蝮蛇抗栓酶,清栓酶等。其作用机理:1降低血粘度 Diabetic peripheral neuropathy is one of the common chronic complications of diabetes. There are four classes of clinical anti-depression drugs, narcotic drugs, non-steroidal anti-inflammatory drugs and neurotrophic drugs, but the curative effect is not good. This article reviews the clinical non-classical drug treatment of the disease for clinicians reference. 1 antithrombotic enzymes [1,2] The commonly used drugs for this class viper antithrombotic enzymes, such as clear thrombin. Its mechanism of action: 1 to reduce blood viscosity