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以仲丁胺和氰酸钾为原料,在85℃下反应2h制得仲丁脲;仲丁脲与乙酰乙酸甲酯在对甲苯磺酸催化下78℃缩合脱水24h得到3-(3-仲丁基)脲-2-丁烯酸甲酯;再与甲醇钠在68℃下环合2h得3-仲丁基-6-甲基脲嘧啶钠盐。用稀盐酸将3-仲丁基-6-甲基脲嘧啶钠盐酸化后得3-仲丁基-6-甲基脲嘧啶,之后与液溴在85℃下反应1h后得目标产品3-仲丁基-6-甲基-5-溴脲嘧啶,总产率为50.52%。中间产物及最终产物用熔点、红外、核磁以及元素分析进行了表征确认。
The reaction of sec-butylamine with potassium cyanate at 85 ℃ for 2h afforded the secondary butyl urea. The secondary butyl urea and methyl acetoacetate were condensed and dehydrated at 78 ℃ for 24 h under the catalysis of p-toluenesulfonic acid to obtain 3- (3-sec- Butyl) urea-2-butenoate; and cyclization with sodium methoxide at 68 ° C for 2h gave 3-sec-butyl-6-methyl uracil sodium salt. 3-sec-butyl-6-methyl uracil sodium hydrochloride was obtained after 3-sec-butyl-6-methyluracil sodium was diluted with dilute hydrochloric acid, and then reacted with liquid bromine at 85 ° C for 1 h to obtain the target product 3- Sec-butyl-6-methyl-5-bromouracil in a total yield of 50.52%. Intermediate and final products were characterized by melting point, IR, NMR and elemental analysis.