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目的：探讨渣驯丸对CCl4引起小鼠急性肝损伤的保护作用。方法将60只昆明种雄性小鼠随机分为6组：正常对照组、模型组、阳性对照组、渣驯丸高、中、低剂量组（1.00 g/kg）、（0.50 g/kg）、（0.25 g/kg）。给药组给予渣驯丸灌胃，每天灌胃两次,连续6 d，正常对照组和CCl4模型组给予等体积生理盐水灌胃。在第6 d灌胃末次给药两小时后，除正常对照组外,其余组均腹腔注射0.1%CCl4石蜡油溶液并在24 h后取材，检测血清中丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）活力以及肝组织中谷胱甘肽过氧化物酶（GSH-PX）、超氧化物歧化酶（T-SOD）、丙二醛（MDA）的活力及含量。结果渣驯丸小剂量组与CCl4模型组相比，血清中ALT、AST的含量明显降低（P<0.05），渣驯丸中剂量组能够降低ALT含量（P<0.05），渣驯丸小剂量组升高超氧化物歧化酶（SOD）活力（P<0.05），渣驯丸大剂量组降低了肝组织中丙二醛（MDA）含量。结论渣驯丸对四氯化碳致肝损伤有一定的保护作用。“,”Objective To discuss the protective effects of the Dragzhun pill against acute liver injury in mice induced by CCl4. Methods Randomly divide seventy Kunming male mice into 6 groups: normal control group, model group, positive control group, the pill high dose group (1.00g/kg), medium dose group (0.50g/kg), low dose group (0.25g/kg). The treatment group was administered by gavage the pills twice daily for 6 consecutive days,while the normal control group and CCl4 model group were given an equal volume of saline. At the end of two hours, except the normal control group, the remaining groups were injected intraperitoneally with 0.1% CCl4 paraffin oil solution. The samples were taken after 24h. The activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gluetanthione peroxiadase (GSH-PX), superoxide dismutase (T-SOD) and malondialdehyde(MDA) in serum were detected. Results The small dose group, comparing to CCl4 model group, the content of ALT and AST in the serum decreased significantly (P<0.05), the medium dose group can reduce ALT levels (P< 0.05), low dose group increased superoxide dismutase (SOD) activity (P<0.05), the high dose group decreased malondialdehyde (MDA) content in liver tissue. Conclusion The Dragzhun pill has a protective effect on hepatic injury induced by carbon tetrachloride.