目的观察舌鳞状细胞癌(鳞癌)患者舌不同部位内微淋巴管密度,获取淋巴管分布的组织计量学参数。方法通过免疫组化法应用D2-40单克隆抗体检测舌体及舌根正常组织不同部位微淋巴管密度。结果舌根粘膜微淋巴管密度为15.2±2.4,舌体粘膜微淋巴管密度为10.1±1.9;舌根肌层微淋巴管密度为9.2±2.3,舌体肌层微淋巴管密度为4.8±1.1。结论舌根部的微淋巴管密度不论是肌层还是粘膜层,均明显高于舌体部。舌体和舌根微淋巴管密度不同,这可能是造成舌根癌和舌体癌淋巴转移率不同的原因所在。 Objective To observe the density of lymphatic vessels in different parts of lingual tongue squamous cell carcinoma (squamous cell carcinoma) and to obtain the lymphatic distribution histomorphometric parameters. Methods By using immunohistochemical method, D2-40 monoclonal antibody was used to detect the lymphatic vessel density in different parts of tongue and tongue base. Results The lingual mucosa lymphatic vessel density was 15.2 ± 2.4, the lingual mucosa lymphatic vessel density was 10.1 ± 1.9, the lingual root muscle lymphatic vessel density was 9.2 ± 2.3, and the lingual myometrium lymphatic vessel density was 4.8 ± 1.1. Conclusions The lymphatic vessel density in the base of the tongue, both muscularis mucosa, was significantly higher than that of the tongue. The density of lymphatic vessels varies between the tongue and the root, which may be responsible for the different rates of lymphatic metastasis in the tongue root and tongue bodies.