目的 探讨手动“肺俞”单穴对支气管哮喘肺组织中白细胞介素-1 β和6的影响.方法 Wistar大鼠随机分为正常对照组、模型组、“肺俞”穴组以及非经非穴组,每组10只.卵蛋白(OVA)制敏、诱导建立哮喘大鼠模型,苏木精-伊红(HE)染色观察大鼠肺组织病理改变、采用酶联免疫吸附试验(ELISA)检测小鼠肺组织匀浆上清白细胞介素-1 β (IL-1 β)和白细胞介素-6 (IL-6)含量.结果 针刺“肺俞”穴能够减轻支气管哮喘模型的炎性病理变化,减轻气道增厚,炎性细胞集聚,与非经穴相比具有明显差别.针刺“肺俞”穴可以下调支气管哮喘中升高的IL-1 β含量(P=0.009),但是手动针刺“肺俞”单穴并不能明显下调支气管哮喘中升高的IL-6含量(P＞0.05).结论 手动针刺“肺俞”单穴对支气管哮喘发病的调节作用可能与下调IL-1 β表达水平相关.“,”Objective To investigate the effect of manual single point “Feishu” acupoint on interleukin-1 beta and interleukin-6 in lung tissue of the asthmatic Wistar rats.Methods 40 Wistar rats were randomly and averagely divided into:normal control group,the model group,the “Feishu” acupoint group and the non-channel-non-acupoint group.HE staining was used to observe the pathological changes of lung tissue,ELISA was used to detect the levels of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) in the lung tissue.Results Acupuncture “Feishu” point can alleviate the inflammatory pathological changes of bronchial asthma model,reduce airway thickening and inflammatory cell aggregation.The acupuncture “Feishu” point could downregulate the elevated IL-lbeta levels in bronchial asthma(P=0.009),but with no effect for the elevated IL-6 content in bronchial asthma(P=0.131).Conclusion The therapeutic effect of acupuncture “Feishu” point on bronchial asthma might be related to the downregulation of IL-1 beta expression.