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目的 研究不同加碘时间 ,不同碘盐浓度变化人群甲状腺功能亢进 (简称甲亢 )流行病学状况及普遍食盐加碘 (USI)对甲亢发病率的影响。方法 四井子乡为碘营养正常地区 ,加碘时间早 ,USI前后补碘速度增加迅速 ;北台子乡为严重缺碘地区 ,USI前后补碘剂量变化不大 ;龙城乡为缺碘地区 ,加碘时间接近USI。针对 3个地区调查 376 19人。同时检测患者甲状腺功能 ,甲状腺自身抗体、甲状腺B超和尿碘含量。结果 3个地区甲亢总发病率由USI前 4.5 3/10万人年 ( 95 %Cl:1.6～ 11.7)增加到USI后的 2 4.5 3/10万人年 ( 95 %Cl :6 .2～ 36 .8)。加碘后人群甲亢发病率的相对危险度(RR)亦增加。结论 补碘时间早 ,甲亢病例出现早 ;补碘速度提高快 ,补碘剂量增加大 ,甲亢发病率亦随之增高。
Objective To study the epidemiological status of hyperthyroidism (Hyperthyroidism) and the effect of universal salt iodization (USI) on the incidence of hyperthyroidism in different iodine times and different iodized salt concentrations. Methods The four wells were in the normal iodine nutrition area, the iodization time was earlier, the iodine supply speed increased rapidly before and after the USI; the North Taiwan sub-area was the severe iodine deficient area, the iodine dosage changed little before and after the USI; Longcheng township was iodine deficiency area, Time is close to USI. 376 19 people surveyed in 3 areas. Thyroid function, thyroid autoantibodies, thyroid B ultrasound and urinary iodine were also detected. Results The overall incidence of hyperthyroidism in the three regions increased from 4.5 3/10 million person years (95% Cl: 1.6 to 11.7) in the USI to 4.53 / 100,000 person years (95% Cl: 6.2-236 .8). The relative risk (RR) of hyperthyroidism also increased after iodization. Conclusion Early iodine supplementation, early cases of hyperthyroidism; iodine fast increase, iodine dose increased, the incidence of hyperthyroidism also increased.