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目的:探讨以健脾温肾、调肝活血、通腑泄浊法为组方原则的甲荣康方对甲状腺功能减退症合并脂代谢异常的临床综合干预效果。方法:将入选的甲减合并脂代谢异常患者60例随机分为甲荣康治疗组(30例)和左旋甲状腺素片对照组(30例),均以8周为1个疗程。以患者的症状体征、甲状腺功能及相关抗体、血脂为主要观察指标,以载脂蛋白、血液流变为次要观察指标,进行疗效观察和对比。结果:甲荣康能明显改善患者的症状体征及甲功、血脂等异常理化指标,疗效优于西药组;甲荣康还能明显改善可以显著改善患者性腺激素和垂体激素的水平,治疗前后均出现显著性差异,且疗效均优于对照组。结论:甲荣康对甲减合并脂代谢异常患者疗效确切,临床干预效果明显,健脾温肾、调肝活血、通腑泄浊法与甲减合并脂代谢异常的病机是吻合的,以此为治则组成的甲荣康方可有效地防治甲状腺功能减退症合并脂代谢异常的发生发展,值得进一步研究和开发。
OBJECTIVE: To investigate the clinical effects of Jia Rong Rong decoction on hypothyroidism complicated with abnormal lipid metabolism with the principles of strengthening the spleen and warming the kidney, regulating the liver and promoting blood flow, and Tongfu decoction method. Methods: Sixty patients with abnormal hypothyroidism and lipid metabolism were randomly divided into two groups: 30 cases in Jia Rong Kang group and 30 cases in control group of levothyroxine tablets. To the patient’s symptoms and signs, thyroid function and related antibodies, blood lipids as the main observation indicators to apolipoprotein, blood rheology as a secondary observation indicators, the efficacy observed and compared. Results: A Rongkang can significantly improve the symptoms and signs of patients and Jiaogan, blood lipids and other abnormal physical and chemical indicators, the effect is better than Western medicine group; A Rongkang can significantly improve the patients can significantly improve the level of sex hormones and pituitary hormone, both before and after treatment Significant differences occurred, and the efficacy is better than the control group. Conclusion: A Rong Kang on hypothyroidism and dyslipidemia in patients with effective curative effect of clinical intervention obvious, spleen Wenshen, transfer of liver and blood circulation, Tongfu decoction method and hypothyroidism and fat metabolism abnormalities are in line with the pathogenesis to This is the rule of the composition of A Rongkang can effectively prevent and treat hypothyroidism associated with the occurrence and development of abnormal lipid metabolism, it is worth further research and development.