论文部分内容阅读
目的探讨活络健骨胶囊对弗氏完全佐剂性关节炎(AdjuvantArthritis,AA)型大鼠的作用及机制。方法采用弗氏完全佐剂(FCA)造模,观测该药对AA鼠关节肿胀度、胸腺、脾重的影响,并测定血清过氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)活力及一氧化氮(NO)、丙二醛(MDA)的含量。结果活络健骨胶囊能减轻AA鼠关节肿胀度及脾的重量,抑制AA鼠体重的减轻,使AA鼠体内降低的SOD、GSH-Px水平升高,并降低血清中病理性增高的NO及MDA的浓度。结论活络健骨胶囊具有良好的抗自由基、抗炎等作用。
Objective To investigate the effect and mechanism of Huoluo Jiangu capsule on rats with Adjuvant Arthritis (AA). Methods The model of Freund’s complete adjuvant (FCA) was used to observe the effect of the drug on joint swelling, thymus, and spleen weight in AA mice, and serum superoxide dismutase (SOD) and glutathione peroxidase (GSH) were measured. GSH-Px) activity and nitric oxide (NO), malondialdehyde (MDA) content. Results Huoluo Jiangu capsule can reduce the degree of joint swelling and spleen weight in AA mice, inhibit the weight loss of AA mice, increase the level of SOD and GSH-Px in AA mice, and reduce the pathological elevation of NO and MDA in serum. concentration. Conclusion Huoluo Jiangu capsule has good anti-free radical and anti-inflammatory effects.