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已经知道有几种物理的和生物学的因素对外周血淋巴细胞培养的SCE和染色体畸变的形成有影响,这是常常用来作为人类和哺乳动物染色体损伤的定量分析的一种方法.在这些影响因素中,个体年龄是重要的生物学因素,在各种方法中都显示年龄明显影响SCE的自发频率.虽然Galloway和Evans及其他学者报道过年龄对SCE的基线频率没有显著的影响,但近几年有一些学者报告年轻人的SCE水平确实比老年人要低些,而新生儿脐带血的淋巴细胞SCE还没有报道.本
It is known that several physical and biological factors have an impact on the formation of SCE and chromosomal aberrations in peripheral blood lymphocyte cultures and are often used as a means of quantitative analysis of chromosomal damage in humans and mammals. Among the influencing factors, individual age is an important biological factor and has shown in various methods that age significantly affects the spontaneous frequency of SCE.Although Galloway and Evans and others have reported that age did not have a significant effect on the baseline frequency of SCE, A few years have some scholars report that young people’s SCE level is indeed lower than the elderly, and neonatal umbilical cord blood lymphocyte SCE has not been reported.