HIV-1是一种淋巴细胞亲和性反转录病毒。感染之初能导致T 细胞活化,但最终造成免疫系统致命性崩溃。HIV-1和靶细胞受体CD_4的相互作用,可导致靶细胞的细胞因子分泌和活化抗原的表达,如IL 2R。虽然HIV-1感染和IL-2R 表达相关联的机制尚不清楚,但有一点是清楚的,病毒在活化的T 细胞而不是静止细胞中进行复制。 HIV-1 is a lymphocyte affinity retrovirus. The beginning of infection can lead to T cell activation, but eventually the deadly immune system collapse. The interaction of HIV-1 with the target cell receptor CD4 leads to the secretion of cytokines by target cells and the expression of activated antigens such as IL2R. Although the mechanism by which HIV-1 infection is associated with IL-2R expression remains unclear, it is clear that the virus replicates in activated T cells rather than in quiescent cells.