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目的探讨婴幼儿期干预治疗对衣原体感染性毛细支气管炎与哮喘相关性的影响。方法采用ELISA方法进行血清CPIgM、IgG测定,将IgM阳性毛细支气管炎患儿作为治疗组,采用大环内酯类药物规范治疗;IgM阴性、IgG阳性既往诊断为毛细支气管炎患儿为对照组,未曾用过大环内酯类药物规范治疗,二组病例均行为期3～5年的随访,比较二者哮喘的发病情况。结果治疗组较对照组哮喘发病率低、治愈率高,治疗组及对照组其哮喘发病率分别为15.56%、36.84%;治愈率分别为73.33%、44.74%(P<0.05)。结论对婴幼儿期衣原体感染性毛细支气管炎采用大环内酯类药规范治疗可降低其日后哮喘发病的风险。
Objective To investigate the effects of infants and young children’s intervention on the correlation between chlamydial infection bronchiolitis and asthma. Methods Serum CPIgM and IgG were measured by ELISA. Children with IgM positive bronchiolitis were treated with macrolides, IgM negative and IgG positive were diagnosed as children with bronchiolitis as control group, Macrolide drugs have not been used normative treatment, the two groups of patients were 3 to 5 years of follow-up, compared the incidence of asthma in both. Results The incidence of asthma in the treatment group was lower than that in the control group, and the cure rate was high. The incidence rates of asthma in the treatment group and the control group were 15.56% and 36.84%, respectively. The cure rates were 73.33% and 44.74%, respectively (P <0.05). Conclusion The treatment of chlamydia trachomatis infantile bronchiolitis by macrolide can reduce the risk of future asthma.