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目的 观察细导管闭式引流腔内灌注白细胞介素 -2和顺铂治疗癌性胸腹水的疗效。方法 49例用细导管闭式引流法将腔内积液引流完 ,再用IL -2 5 0万u～ 10 0万u ;DDP 60mg～ 80mg腔内灌注。结果 完全缓解 (CR) 2 4例 ,部分缓解 (PR) 2 1例 ,总有效率 (CR +PR) 91 8%。毒副反应较轻 ,主要为轻度消化道反应和骨髓抑制。结论 细导管闭式引流腔内灌注IL -2和DDP治疗癌性胸腹水疗效较高 ,毒副反应少 ,值得推广应用。
Objective To observe the effect of intravascular perfusion of interleukin-2 and cisplatin in the treatment of malignant thoracic and ascites fluid in a closed tube with a small catheter. Methods Forty-nine patients were treated with a closed catheter and closed drainage method. The IL-250 000 u-1000 000 u was used. DDP 60 mg-80 mg was intraperfused. Results Complete remission (CR) in 24 patients, partial remission (PR) in 21 patients, total effective rate (CR +PR) 91 8%. The toxic side effects were mild, mainly mild gastrointestinal reactions and myelosuppression. Conclusion Intracoronary infusion of IL-2 and DDP in the closed closed canal catheter has a higher curative effect and fewer toxic and side effects. It is worthy of popularization and application.