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饱餐和扩张胃对心血管的影响早已引起人们的注意,但结论是不一致的。以往的实验都是在正常冠脉的动物上进行。本文在造成冠脉狭窄的情况下进行观察。在22条开胸狗的左旋支上,用微米狭窄器造成临界狭窄和重度狭窄。把一个气球送入胃中并充气600ml连续观察30min。正常冠脉组在扩张胃的最初15min内(前期)冠脉流量增多,主动脉压升高,血管总阻力下降,冠脉扩张;在扩张胃后15分钟(后期)无显著变化。冠脉临界狭窄组,前期冠脉流量增多,血管总阻力下降,冠脉扩张;后期流量减少,壁内血管阻力增加,冠脉收缩。冠脉重度狭窄组,前期冠脉流量无明显增加;后期流量显著减少,血管总阻力及心外膜、壁内血管阻力均增加,提示左旋支血管各段都发生收缩。 我们认为,餐后心绞痛的发作可能主要是在原有冠脉狭窄基础上冠脉流量进一步减少的结果。
The effects of full meal and dilated stomach on cardiovascular have drawn attention, but the conclusion is inconsistent. Previous experiments were performed on animals with normal coronary arteries. This article in the case of coronary stenosis was observed. On the left thoracotomy of the 22 thoracotomy dogs, a critical stenosis and a severe stenosis were caused by the micrometer stenosis. A balloon into the stomach and inflated 600ml continuous observation of 30min. In the normal coronary artery group, the coronary flow increased, the aortic pressure increased, the total vascular resistance decreased and the coronary artery dilated in the first 15 min of dilatation of the stomach (early period). No significant change was observed 15 min after the dilatation of the stomach. Coronary stenosis group, pre-coronary flow increased, decreased total vascular resistance, coronary dilatation; late flow decreased wall vascular resistance increased coronary contractions. Coronary stenosis group, no significant increase in coronary flow; early postoperative flow decreased significantly, total vascular resistance and epicardial and intramural vascular resistance were increased, suggesting that all segments of left ventricular branches have occurred contraction. In our opinion, the incidence of postprandial angina may be mainly the result of further reduction of coronary flow on the basis of the original coronary stenosis.