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目的探讨甘肃武威地区汉族人口非酒精性脂肪肝(NAFLD)的临床特点和相关危险因素。方法运用回顾性分析结合多元Logistic回归分析,探讨2003年3月～2006年3月武威市人民医院门诊体检的180例武威地区汉族人口NAFLD的临床特点和相关危险因素并与180例正常对照组进行比较。结果NAFLD组血清ALT和AST异常率均高于对照组,其中又以ALT异常率的增高更加明显。与对照组相比,易伴发肥胖、Ⅱ型糖尿病、心脑血管疾病、高脂血症等疾病。体重指数(BMI)、舒张压(DBP)、高脂饮食、甘油三脂(TG)和载脂蛋白B(ApoB)与NAFLD的发生呈负相关关系,高密度脂蛋白(HDL)与NAFLD的发生呈正相关关系。结论BMI、DBP、高脂饮食、TG和ApoB为NAFLD的独立危险因素,HDL为其保护因素。定期体检、控制血脂水平、改善原有的不良饮食结构、加强锻炼、控制体重为预防NAFLD及其伴发疾病的重要措施。
Objective To investigate the clinical characteristics and related risk factors of non-alcoholic fatty liver disease (NAFLD) in Han population in Wuwei district of Gansu province. Methods Retrospective analysis and multivariate Logistic regression analysis were used to investigate the clinical characteristics and risk factors of 180 NAFLD Han population in Wuwei district from March 2003 to March 2006 in Wuwei People’s Hospital and compared with 180 healthy controls Compare Results The abnormal rates of ALT and AST in serum of NAFLD group were higher than that of control group, and the abnormality rate of ALT was more obvious. Compared with the control group, easily accompanied by obesity, type II diabetes, cardiovascular disease, hyperlipidemia and other diseases. The body mass index (BMI), diastolic blood pressure (DBP), high fat diet, triglyceride (TG) and apolipoprotein B (ApoB) were negatively correlated with the occurrence of NAFLD. The occurrence of high density lipoprotein (HDL) and NAFLD There was a positive correlation. Conclusion BMI, DBP, high-fat diet, TG and ApoB are independent risk factors for NAFLD and HDL is the protective factor. Regular physical examination, blood lipid levels, improve the original poor diet, exercise, weight control as an important measure to prevent NAFLD and its associated diseases.