论文部分内容阅读
目的:Meta分析p53基因第72位密码子多态性和结直肠癌发病易感性的关系。方法:从Medline,Embase和CNKI数据库中检索研究p53基因第72位密码子多态性与和结直肠癌易感性关系的公开发表论文,使用Stata软件合成分析p53各基因型与结直肠癌易感性的关系。使用比值比(Odds Ratio,OR)和95%可信区间(95%Confidence Interval,95%CI)作为效应指标。同时评价所纳入研究的异质性及发表偏移。结果:共有12篇关于p53基因第72位密码子多态性和结直肠癌易感性的公开发表论文被纳入本研究。12篇纳入文献中总共包括病例2459例,对照3632例。合成分析发现p53基因第72位密码子的Arg等位基因、ArgPro基因型和Pro等位基因分布的比值比(OR)和95%可信区间(95%CI)分别为[1.03;0.89～1.18],[0.98;0.89～1.08]和[1.10;0.94～1.31]。以研究人群进行亚组分层分析发现亚洲人中p53基因的Arg等位基因、ArgPro基因型和Pro等位基因分布的OR和95%CI分别为[0.90;0.68～1.19],[1.04;0.90～1.21]和[1.20;0.82～1.77];在高加索人中p53基因的Arg等位基因、ArgPro基因型和Pro等位基因分布的OR和95%CI分别为[1.07;0.95～1.20],[0.94;0.83～1.07]和[0.91;0.70～1.17]。通过Begger和Egger方法检测均未发现存在发表偏移。结论:本研究提示p53基因第72位密码子多态性与结直肠癌的发病率无直接关系,p53基因多态性可能不是结直肠癌易感性的独立影响因素。
OBJECTIVE: To analyze the association between p53 codon 72 codon usage and susceptibility to colorectal cancer in Meta-analysis. METHODS: The published papers on the relationship between p53 codon 72 codon usage and the susceptibility to colorectal cancer were searched from Medline, Embase and CNKI databases. Stata software was used to analyze the association between p53 genotypes and colorectal cancer susceptibility Relationship. Odds Ratio (OR) and 95% Confidence Interval (95% CI) were used as effect indicators. The heterogeneity and publication bias of the included studies were also evaluated. RESULTS: A total of 12 published papers on p53 codon 72 polymorphism and susceptibility to colorectal cancer were included in this study. A total of 12 articles included in the literature 2459 cases, control 3632 cases. Synthesized analysis showed that the odds ratio (OR) and 95% confidence interval (95% CI) of Arg allele, ArgPro genotype and Pro allele of codon 72 of p53 gene were [1.03; 0.89-1.18 ], [0.98; 0.89 ~ 1.08] and [1.10; 0.94 ~ 1.31]. A subgroup analysis of the study population found that the OR and 95% CIs of Arg, ArgPro and Pro alleles of the p53 gene in Asians were [0.90; 0.68-1.19], [1.04; 0.90 ~ 1.21] and [1.20; 0.82-1.77]. The OR and 95% CI of the Arg allele, ArgPro genotype and Pro allele of the p53 gene were [1.07; 0.95-1.20] in Caucasians, 0.94; 0.83-1.07] and [0.91; 0.70-1.17]. No post offset was found by Begger and Egger methods. Conclusion: This study suggests that there is no direct relationship between the codon 72 polymorphism of p53 gene and the incidence of colorectal cancer. The p53 gene polymorphism may not be an independent factor of colorectal cancer susceptibility.