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目的研究并验证小剂量米索前列醇配伍依沙吖啶终止中期妊娠效果,寻求一种安全有效,能明显缩短产程的引产方法。方法根据随机数字表将160例孕14～27周需要引产的健康孕妇随机等分为两组。研究组80例,先按常规行羊膜腔穿刺注入依沙吖啶100mg,术毕即于阴道后穹窿处放置米索前列醇50μg;对照组80例,只常规行羊膜腔穿刺注入依沙吖啶100mg。结果研究组单次引产成功率(93.8%)高于对照组(77.5%),差异有显著性(P<0.05);研究组胎儿排出时间为(35.2±10.2)h,短于对照组的(47.5±12.5)h,两组比较,差异有显著性(P<0.01);研究组宫颈裂伤率(2.5%)低于对照组(11.3%),差异有显著性(P<0.05);与对照组相比,研究组产后出血量、胎盘排出,均未受明显影响,不增加各种并发症和不良反应的发生率。结论米索前列醇配伍依沙吖啶引产明显提高了单次引产的成功率,大大缩短引产所需的时间,同时降低了宫颈裂伤率。因此只要严格掌握适应证,这是一种安全、高效、廉价、方便的引产方法,值得推广。
Objective To study and verify the effect of small dose misoprostol combined with ethacridine on termination of mid-term pregnancy and seek a safe and effective method of induction of labor with shortened labor. Methods According to the random number table, 160 pregnant women who needed induction of labor during 14-27 weeks of gestation were randomly divided into two groups. The study group of 80 patients, according to the conventional amniocentesis by first injection of ethacridine 100mg, surgery at the vaginal fornix placed misoprostol 50μg; control group of 80 patients, only routine amniocentesis injection of ethacridine 100mg. Results The success rate of single induction was 93.8% in study group and 77.5% in control group (P <0.05). The discharge time of study group was (35.2 ± 10.2) h, which was shorter than that in control group 47.5 ± 12.5) h, the difference was significant between the two groups (P <0.01). The rate of cervical laceration in study group (2.5%) was lower than that in control group (11.3% Compared with the control group, the study group postpartum hemorrhage, placental discharge were not significantly affected, does not increase the incidence of various complications and adverse reactions. Conclusion Misoprostol combined with ethacridine induction significantly increased the success rate of single induction, shortening the time required for induction of labor and reducing the rate of cervical laceration. Therefore, as long as the indications are strictly controlled, this is a safe, efficient, cheap and convenient induction method that is worth promoting.