目的观察中心静脉导管注入胸腺法新联合顺铂治疗恶性胸腔积液的疗效及不良反应。方法选择恶性胸腔积液患者86例,胸腔中心静脉置管行闭式引流并腔内注入胸腺法新联合顺铂,每周1次。结果总有效率为83.7%,生活质量评分提高10～20分,不良反应少。结论中心静脉导管注入胸腺法新联合顺铂治疗恶性胸腔积液,疗效肯定,不良反应轻。 Objective To observe the efficacy and adverse reactions of central venous catheters in the treatment of malignant pleural effusion with thymus plus cisplatin. Methods Eighty-six patients with malignant pleural effusions were selected. The central venous catheter was closed and the thoracic cisplatin was injected into the cavity once a week. The total effective rate was 83.7%, and the quality of life score increased by 10 to 20 points with less adverse reactions. Conclusions Infusion of thymus plus cisplatin in the treatment of malignant pleural effusion with central venous catheter has a positive effect and mild adverse reactions.