由于胰泌素(Secretin)在体内的释放是pH敏感的,作者乃设计以聚丙酰氯-赖氨酸为单体,采用界面聚合法制备微囊体系,并以此模式在不同pH介质中药物的释放速度进行研究。药物释放与测定:取微囊(直径5～10μm)在四种不同pH缓冲液中进行释放,24小时达平衡,取上清液,于波长245nm处测光密度。结果表明,至少有80%药物按零级速度释放,在PH_2介质中释放最快,于6 Since the release of Secretin in the body is pH-sensitive, the authors designed a microcapsule system using interfacial polymerization using poly (propionyl chloride) -lysine as a monomer. In this mode, Release speed research. Drug release and determination: The microcapsules (5 ~ 10μm in diameter) were released in four different pH buffers and equilibrated for 24 hours. Supernatants were taken and measured at a wavelength of 245nm. The results showed that at least 80% of the drug released at zero speed, the fastest release in PH_2 medium, at 6