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目的:观察泄浊饮对湿热内阻型2型糖尿病伴高尿酸血症患者早期肾功能的影响。方法:将60例符合诊断标准的患者随机分为治疗组和对照组,均行糖尿病降糖西药基础治疗,治疗组加用泄浊饮。开始治疗以及治疗8周后分别检测空腹血糖、餐后两小时血糖、血尿酸、尿微量白蛋白(mALB)、尿N-乙酰-β-D氨基葡糖苷酶(尿NAG),并进行湿热内阻证症状量化评分。结果:两组治疗8周后血尿酸、尿mALB、尿NAG和证候症状量化积分与开始治疗时相比均有所下降,但治疗组比对照组效果显著,两组差异比较有统计学意义(P<0.05)。结论:泄浊饮对湿热内阻型2型糖尿病伴高尿酸血症患者早期肾功能的改善有较好临床效果。
Objective: To observe the effect of Xiezhuo Yin on early renal function in patients with type 2 diabetes mellitus with dampness and heat resistance and hyperuricemia. Methods: Sixty patients with diagnostic criteria were randomly divided into treatment group and control group. All patients underwent diabetes mellitus and western medicine. The treatment group was given Xiezhuo Yin. Fasting blood glucose, blood glucose, serum uric acid, urine microalbumin (MALB) and urinary N-acetyl-β-D glucosaminidase (urine NAG) were measured respectively at the beginning of treatment and after 8 weeks of treatment, Obstacle symptom quantification score. Results: After 8 weeks of treatment, the quantitative integral of serum uric acid, urine mALB, urinary NAG and syndrome symptoms decreased compared with the initial treatment, but the treatment group was more effective than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion: Xiezhuo Yin has good clinical effect on the improvement of early renal function in patients with type 2 diabetes mellitus with damp-heat and type 2 diabetes mellitus.