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51例麻风病人,接受B663长期治疗,并且经受各种临床检验以探测其毒性作用。观察了大约220病人年,分析了大约4万个试验结果。其血清转氨酶、麝香草酚浊度、血清球旦白、硷性磷酸酶、白细胞计数和分类,血球容积、血尿素氮、血清肌酐、血胆固醇、血清白旦白、血钾、血钙、大便潜血、尿常规及网状红血球等,均未发现异常。虽然有血糖升高、血清胆红质增高,但均系少量的,并未引起有关的临床体征,似乎也并不具有较大的临床意义。尽管此药可以在许多组织中沉积,但是在临床上并不显示严重的或影响生命的毒性作用。虽然因为有皮肤及胃肠道的副作用限制了此药的用途,但至今在治疗麻风病人上其有利方面依旧超过它的不利方面。
Fifty-one patients with leprosy received long-term treatment with B663 and underwent various clinical tests to detect their toxic effects. About 220 patient years were observed, and about 40,000 test results were analyzed. Serum transaminase, thymol turbidity, serum globulin, alkaline phosphatase, white blood cell count and classification, hematocrit, blood urea nitrogen, serum creatinine, blood cholesterol, serum white denier, serum potassium, blood calcium, stool Occult blood, urinary routine and reticulocyte, etc., were found no abnormalities. Although there is elevated blood sugar, serum bilirubin increased, but a small amount of the system did not cause the clinical signs, it seems that does not have a greater clinical significance. Although this drug can be deposited in many tissues, it does not clinically show serious or life-threatening toxic effects. Although the use of this medicine has been limited because of skin and gastrointestinal side effects, so far its advantages in treating leprosy patients still outweigh its disadvantages.