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测定１９９１年９月至１９９３年９月收集到的８９２株临床分离菌株对诺氟沙星、依诺沙星、氧氟沙星、洛美沙星及环丙沙星的敏感性，将结果进行归纳总结，并用部分菌株作体外抗菌活性测定。结果在８９２株菌中，对５种喳诺酮类药物敏感６７５株，耐药２１７株，耐药率为２４．３％。耐１种药者１６。９％，耐２种药者４．７％，耐３种药者２．２％，耐４种药者０．４％。对５种喹诺酮类药物的耐药率分别为：诺氟沙星２９．９％、依诺沙星１９．２％、氧氟沙星２０．１％、洛美沙星３８．１％、环丙沙星１４．４％。耐药率１９９１年为１３．４％、１９９２年２４．０％、１９９３年３２．１％。体外抗菌活性结果表明：５种喹诺酮类药物的ＭＩＣ５０分别为０，２５、０．９３、０．１２５、０．４３、０．０６ｍｇ／Ｌ。综上可知：喹诺酮类抗菌药物对临床分离菌株具有很好的体外抗菌活性，但耐药菌株也广泛存在，且呈逐年上升趋势。对洛美沙星的耐药率最后，对环丙沙星的耐药率最低。
The sensitivity of 892 clinical isolates collected from September 1991 to September 1993 to norfloxacin, enoxacin, ofloxacin, lomefloxacin and ciprofloxacin was determined and the results were summarized Summary, and with some strains for in vitro antibacterial activity determination. Results Among the 892 strains, 675 strains were susceptible to 5 kinds of quinolones, and 217 strains were resistant. The resistance rate was 24.3%. 16.9% were resistant to one kind of medicine, 4.7% were resistant to two kinds of medicine, 2.2% were resistant to three kinds of medicine and 0.4% were resistant to four kinds of medicine. Resistant rates to five quinolones were 29.9% for norfloxacin, 19.2% for enoxacin, 20.1% for ofloxacin, 38.1% for lomefloxacin, Sand star 14.4%. The rate of resistance was 13.4% in 1991, 24.0% in 1992 and 32.1% in 1993. The results of antibacterial activity in vitro showed that MIC50 of five quinolones were 0,25,0.93,0.125,0.43,0.06mg / L respectively. In conclusion, quinolone antibacterials have very good in vitro antibacterial activity against clinical isolates, but resistant isolates also exist extensively, and they show an increasing trend year by year. Resistance to lomefloxacin Finally, the rate of resistance to ciprofloxacin was the lowest.